MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties

Gut-associated dendritic cells (DC) synthesize all-trans retinoic acid (RA), which is required for inducing gut-tropic lymphocytes. Gut-associated DC from MyD88(-/-) mice, which lack most TLR signals, expressed low levels of retinal dehydrogenases (Raldh, critical enzymes for RA biosynthesis) and we...

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Bibliografische gegevens
Hoofdauteurs: Wang, Sen, Villablanca, Eduardo J., De Calisto, Jaime, Gomes, Daniel C. O., Nguyen, Deanna D., Mizoguchi, Emiko, Kagan, Jonathan C., Reinecker, Hans-Christian, Hacohen, Nir, Nagler, Cathryn, Xavier, Ramnik J., Rossi-Bergmann, Bartira, Chen, Yi-Bin, Blomhoff, Rune, Snapper, Scott B., Mora, J. Rodrigo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119749/
https://ncbi.nlm.nih.gov/pubmed/21646294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003740
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