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Cellular competition independent of BAFF/BLyS results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments

The peripheral B cell pro-survival cytokine BAFF/BLyS has been proposed to participate in the regulation of immunological tolerance. Selective elimination or reconstitution of B cells expressing transgene-encoded, autoreactive BCRs upon systemic BLyS depletion or supplementation, respectively, was o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nikbakht, Neda, Migone, Thi-Sau, Ward, Chris P., Manser, Tim
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119736/
https://ncbi.nlm.nih.gov/pubmed/21632709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003924
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