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A Glu113Ala mutation within a factor VIII Ca(2+) binding site enhances cofactor interactions in factor Xase
We recently identified an acidic-rich segment in the A1 domain of factor VIII (residues 110–126) that functions in the coordination of Ca(2+), an ion necessary for cofactor activity (Wakabayashi et al., J. Biol. Chem. 279:12677–12684, 2004). Mutagenesis studies showed that replacement of residue Glu...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3119506/ https://ncbi.nlm.nih.gov/pubmed/16042406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi050638t |
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