In Hepatic Fibrosis, Liver Sinusoidal Endothelial Cells Acquire Enhanced Immunogenicity

The normal liver is characterized by immunologic tolerance. Primary mediators of hepatic immune tolerance are liver sinusoidal endothelial cells (LSECs). LSECs block adaptive immunogenic responses to Ag and induce the generation of T regulatory cells. Hepatic fibrosis is characterized by both intens...

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Autori principali: Connolly, Michael K., Bedrosian, Andrea S., Malhotra, Ashim, Henning, Justin R., Ibrahim, Junaid, Vera, Valery, Cieza-Rubio, Napoleon E., Hassan, Burhan U., Pachter, H. Leon, Cohen, Steven, Frey, Alan B., Miller, George
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119346/
https://ncbi.nlm.nih.gov/pubmed/20639479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000332
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