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Intracellular targeting of peroxiredoxin 6 to lysosomal organelles requires MAPK activity and binding to 14-3-3ε

Peroxiredoxin 6 (Prdx6), a bifunctional protein with GSH peroxidase and lysosomal-type phospholipase A(2) activities, has been localized to both cytosolic and acidic compartments (lamellar bodies and lysosomes) in lung alveolar epithelium. We postulate that Prdx6 subcellular localization affects the...

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Autors principals: Sorokina, Elena M., Feinstein, Sheldon I., Zhou, Suiping, Fisher, Aron B.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118628/
https://ncbi.nlm.nih.gov/pubmed/21346153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00285.2010
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