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Activation of the Stress Protein Response Inhibits the STAT1 Signaling Pathway and iNOS function in Alveolar Macrophages: Role of Hsp90 and Hsp70

Activation of the stress protein response (SPR) inhibits iNOS-dependent release of NO from alveolar macrophages by blocking the activation of the STAT1 pathway in response to IFN-γ, a major cytokine present in the airspace of patients with acute lung injury. Inhibition of STAT1 phosphorylation after...

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Autors principals: Howard, Marybeth, Roux, Jérémie, Lee, Hyon, Miyazawa, Byron, Gartland, Brandi, Howard, Amanda J., Pittet, Jean-François
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118552/
https://ncbi.nlm.nih.gov/pubmed/20388761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thx.2008.101139
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