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Increasing gene dosage greatly enhances recombinant expression of aquaporins in Pichia pastoris

BACKGROUND: When performing functional and structural studies, large quantities of pure protein are desired. Most membrane proteins are however not abundantly expressed in their native tissues, which in general rules out purification from natural sources. Heterologous expression, especially of eukar...

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Main Authors: Nordén, Kristina, Agemark, Maria, Danielson, Jonas ÅH, Alexandersson, Erik, Kjellbom, Per, Johanson, Urban
格式: Artigo
語言:Inglês
出版: BioMed Central 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118338/
https://ncbi.nlm.nih.gov/pubmed/21569231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-11-47
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