Effect Of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle

We report here that the DNA-dependent protein kinase (DNA-PK) affects the molecular fate of the recombinant adeno-associated virus (rAAV) genome in skeletal muscle. rAAV-human α1-antitrypsin (rAAV-hAAT) vectors were delivered by intramuscular injection to either C57BL/6 (DNA-PKcs(+)) or C57BL/6-SCID...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Song, Sihong, Laipis, Philip J., Berns, Kenneth I., Flotte, Terence R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31183/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274433/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061014598
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