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P53 conformational switching for selectivity may reveal a general solution for specific DNA binding
This article highlights the role of conformational changes in p53 in dictating DNA-binding specificity as described by the Halazonetis laboratory in this issue and extends this principle to other systems such as proteins involved in recognizing specific types of DNA damage.
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117650/ https://ncbi.nlm.nih.gov/pubmed/21629273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.133 |
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