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An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
The p53 tumour suppressor gene, the most frequently mutated gene in human cancer, encodes a transcription factor that contains sequence-specific DNA binding and homo-tetramerization domains. Interestingly, the affinities of p53 for specific and non-specific DNA sites differ by only one order of magn...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117648/ https://ncbi.nlm.nih.gov/pubmed/21522129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.127 |
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