The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the Malaria parasite Plasmodium falciparum

Plasmodium falciparum, the major causative agent of human malaria contains three separate genomes. The apicoplast, an intracellular organelle contains a ∼35kb circular DNA genome of unusually high A/T content (>86%) that is replicated by the nuclear encoded replication complex Pfprex. Herein, we...

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Bibliographic Details
Main Authors: Kennedy, Scott R., Chen, Cheng-Yao, Schmitt, Michael W., Bower, Cole N., Loeb, Lawrence A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117635/
https://ncbi.nlm.nih.gov/pubmed/21570407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.04.071
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