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Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms

Secondary metabolites from microorganisms have a broad spectrum of applications, particularly in therapeutics. The growing number of sequenced microbial genomes has revealed a remarkably large number of natural product biosynthetic clusters for which the products are still unknown. These cryptic clu...

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Hlavní autoři: Chiang, Yi-Ming, Chang, Shu-Lin, Oakley, Berl R., Wang, Clay C. C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117463/
https://ncbi.nlm.nih.gov/pubmed/21111669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2010.10.011
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