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Reversing the aging stromal phenotype prevents carcinoma initiation

The accumulation of senescent stromal cells in aging tissue changes the local microenvironment from normal to a state similar to chronic inflammation. This inflammatory microenvironment can stimulate the proliferation of epithelial cells containing DNA mutations which can ultimately lead to cancer....

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Main Authors: Lewis, Davina A., Travers, Jeffrey B., Machado, Christiane, Somani, Ally-Khan, Spandau, Dan F
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117456/
https://ncbi.nlm.nih.gov/pubmed/21515933
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