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Identification and Validation of Notch Pathway Activating Compounds through a Novel High-Throughput Screening Method
Carcinoids are neuroendocrine (NE) tumors with limited treatment options. Notch activation has been shown to suppress growth and hormone production in carcinoid cells. In this study, we provide a process for identifying Notch activating compounds using a high throughput screen (HTS), and we validate...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117093/ https://ncbi.nlm.nih.gov/pubmed/21425138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.25652 |
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