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Proportional odds model for dose finding clinical trial designs with ordinal toxicity grading
Currently many dose finding clinical trial designs, including the continual reassessment method (CRM) and the standard ‘3+3’ design, dichotomize toxicity outcomes based on pre-specified dose-limiting toxicity criteria. This loss of information is particularly inefficient due to the small sample size...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117067/ https://ncbi.nlm.nih.gov/pubmed/21344472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.4069 |
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