Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis

Chronic intestinal inflammation culminates in cancer and a link to TLR4 has been suggested by our observation that TLR4 deficiency prevents colitis-associated neoplasia. In the current study, we address the effect of the aberrant activation of epithelial TLR4 on induction of colitis and colitis-asso...

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Detalhes bibliográficos
Main Authors: Fukata, Masayuki, Shang, Limin, Santaolalla, Rebeca, Sotolongo, John, Pastorini, Cristhine, España, Cecilia, Ungaro, Ryan, Harpaz, Noam, Cooper, Harry S., Elson, Greg, Kosco-Vilbois, Marie, Zaias, Julia, Perez, Maria T., Mayer, Lloyd, Vamadevan, Arunan S., Lira, Sergio A., Abreu, Maria T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117047/
https://ncbi.nlm.nih.gov/pubmed/21674704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21527
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