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Disruption of LRRK2 Does Not Cause Specific Loss of Dopaminergic Neurons in Zebrafish

Mutations in LRRK2 are genetically linked to Parkinson's disease (PD) but its normal biological function is largely unknown. Sheng et al. recently reported that deletion of the WD40 domain of LRRK2 in zebrafish specifically causes PD-like loss of neurons and behavior defect. However, our simila...

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Detalhes bibliográficos
Main Authors: Ren, Guiqi, Xin, Shengchang, Li, Song, Zhong, Hanbing, Lin, Shuo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116841/
https://ncbi.nlm.nih.gov/pubmed/21698186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020630
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