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Wnt signaling is activated at high frequency and drives proliferation of multiple human sarcoma subtypes through a TCF/β-catenin target gene, CDC25A
Wnt canonical signaling is critical for normal development as well as homeostasis of several epithelial tissues, and constitutive activation of this pathway is commonly observed in carcinomas. We show here that 50% of human sarcomas (n=45) and 70% of sarcoma cell lines (n=23) of diverse histological...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3116447/ https://ncbi.nlm.nih.gov/pubmed/21575861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.03.010 |
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