Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition and is currently exploited in clinical treatment of HR-deficient tumors. Here we show that mild hyperthermia (41–42.5 °C) induces degradation o...

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Hlavní autoři: Krawczyk, Przemek M., Eppink, Berina, Essers, Jeroen, Stap, Jan, Rodermond, Hans, Odijk, Hanny, Zelensky, Alex, van Bree, Chris, Stalpers, Lukas J., Buist, Marrije R., Soullié, Thomas, Rens, Joost, Verhagen, Hence J. M., O'Connor, Mark J., Franken, Nicolaas A. P., ten Hagen, Timo L. M., Kanaar, Roland, Aten, Jacob A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116433/
https://ncbi.nlm.nih.gov/pubmed/21555554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101053108
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