Influenza A Virus Nucleoprotein Exploits Hsp40 to Inhibit PKR Activation

BACKGROUND: Double-stranded RNA dependent protein kinase (PKR) is a key regulator of the anti-viral innate immune response in mammalian cells. PKR activity is regulated by a 58 kilo Dalton cellular inhibitor (P58(IPK)), which is present in inactive state as a complex with Hsp40 under normal conditio...

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Bibliografiske detaljer
Main Authors: Sharma, Kulbhushan, Tripathi, Shashank, Ranjan, Priya, Kumar, Purnima, Garten, Rebecca, Deyde, Varough, Katz, Jacqueline M., Cox, Nancy J., Lal, Renu B., Sambhara, Suryaprakash, Lal, Sunil K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115951/
https://ncbi.nlm.nih.gov/pubmed/21698289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020215
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