Influenza A Virus Nucleoprotein Activates the JNK Stress-Signaling Pathway for Viral Replication by Sequestering Host Filamin A Protein

Influenza A virus (IAV) poses a major threat to global public health and is known to employ various strategies to usurp the host machinery for survival. Due to its fast-evolving nature, IAVs tend to escape the effect of available drugs and vaccines thus, prompting the development of novel antiviral...

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Main Authors: Anshika Sharma, Jyoti Batra, Olga Stuchlik, Matthew S. Reed, Jan Pohl, Vincent T. K. Chow, Suryaprakash Sambhara, Sunil K. Lal
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-09-01
Colecção:Frontiers in Microbiology
Assuntos:
protein-protein interaction
host-virus interaction
actin-binding proteins
IAV replication
next generation anti-influenza target
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmicb.2020.581867/full
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