Multiple Actions of Spinophilin Regulate Mu Opioid Receptor Function

Spinophilin, a dendritic spine-enriched scaffold protein, modulates synaptic transmission via multiple functions mediated by distinct domains of the protein. Here, we show that spinophilin is a key modulator of opiate action. Knockout of the spinophilin gene causes reduced sensitivity to the analges...

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Autors principals: Charlton, Joanna J., Allen, Patrick B., Psifogeorgou, Kassi, Chakravarty, Sumana, Gomes, Ivone, Neve, Rachael L., Devi, Lakshmi A., Greengard, Paul, Nestler, Eric J., Zachariou, Venetia
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115895/
https://ncbi.nlm.nih.gov/pubmed/18439408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.02.006
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