Thrombin Mutant W215A/E217A Treatment Improves Neurological Outcome and Reduces Cerebral Infarct Size in a Mouse Model of Ischemic Stroke

BACKGROUND AND PURPOSE: Treatment of ischemic stroke by activation of endogenous plasminogen using tissue plasminogen activator (tPA) is limited by bleeding side effects. In mice, treatment of experimental ischemic stroke with activated protein C (APC) improves outcomes; however, APC also has bleedi...

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Autori principali: Berny-Lang, Michelle A., Hurst, Sawan, Tucker, Erik I., Pelc, Leslie A., Wang, Ruikang K., Hurn, Patricia D., Di Cera, Enrico, McCarty, Owen J.T., Gruber, András
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115697/
https://ncbi.nlm.nih.gov/pubmed/21512172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.110.603811
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