Strong linkage disequilibrium of a HbE variant with the (AT)(9)(T)(5) repeat in the BP1 binding site upstream of the β-globin gene in the Thai population

A binding site for the repressor protein BP1, which contains a tandem (AT)(x)(T)(y) repeat, is located approximately 530 bp 5′ to the human β-globin gene (HBB). There is accumulating evidence that BP1 binds to the (AT)(9)(T)(5) allele more strongly than to other alleles, thereby reducing the express...

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Detalhes bibliográficos
Main Authors: Ohashi, Jun, Naka, Izumi, Patarapotikul, Jintana, Hananantachai, Hathairad, Brittenham, Gary, Looareesuwan, Sornchai, Clark, Andrew G., Tokunaga, Katsushi
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114417/
https://ncbi.nlm.nih.gov/pubmed/15551156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10038-004-0210-z
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