Evaluation of two mutants of Mycobacterium avium subsp. paratuberculosis as candidates for a live attenuated vaccine for Johne’s disease

Control of Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis, has been difficult because of a lack of an effective vaccine. To address this problem we used targeted gene disruption to develop candidate mutants with impaired capacity to survive ex vivo and in vivo to test as a va...

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Main Authors: Park, Kun Taek, Allen, Andrew J., Bannantine, John P., Seo, Keun Seok, Hamilton, Mary J., Abdellrazeq, Gaber S., Rihan, Heba M., Grimm, Amanda, Davis, William C.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114198/
https://ncbi.nlm.nih.gov/pubmed/21565243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.04.090
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