Uric Acid Induces Trophoblast Il-1β Production Via The Inflammasome: Implications For The Pathogenesis Of Preeclampsia

PROBLEM: Preeclampsia is associated with hyperuricemia, which correlates with the disease severity. Levels of circulating uric acid increase before the clinical manifestations, suggesting they may be causally related. Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, lead...

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Main Authors: Mulla, Melissa J., Myrtolli, Kledia, Potter, Julie, Boeras, Crina, Kavathas, Paula B., Sfakianaki, Anna K., Tadesse, Serkelem, Norwitz, Errol R., Guller, Seth, Abrahams, Vikki M.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114103/
https://ncbi.nlm.nih.gov/pubmed/21352397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0897.2010.00960.x
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