IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides

The airway epithelium forms a barrier against infection but also produces antimicrobial peptides (AMPs) and other inflammatory mediators to activate the immune system. It has been shown that in allergic disorders, Th2 cytokines may hamper the antimicrobial activity of the epithelium. However, the pr...

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Bibliografiske detaljer
Main Authors: Zuyderduyn, Suzanne, Ninaber, Dennis K, Schrumpf , Jasmijn A, van Sterkenburg, Marianne AJA, Verhoosel, Renate M, Prins, Frans A, van Wetering, Sandra, Rabe, Klaus F, Hiemstra, Pieter S
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113720/
https://ncbi.nlm.nih.gov/pubmed/21529380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-12-59
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