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TGF-β1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms

Airway epithelium is an important site for local vitamin D (VD) metabolism; this can be negatively affected by inflammatory mediators. VD is an important regulator of respiratory host defense, for example, by increasing the expression of hCAP18/LL-37. TGF-β1 is increased in chronic obstructive pulmo...

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Bibliografiske detaljer
Udgivet i:J Innate Immun
Main Authors: Schrumpf, Jasmijn A., Ninaber, Dennis K., van der Does, Anne M., Hiemstra, Pieter S.
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959102/
https://ncbi.nlm.nih.gov/pubmed/30970352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000497415
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