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Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium

Valproic acid (VPA) is the most highly prescribed epilepsy treatment worldwide and is also used to prevent bipolar disorder and migraine. Surprisingly, very little is known about its mechanisms of cellular uptake. Here, we employ a range of cellular, molecular and genetic approaches to characterize...

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Autors principals: Terbach, Nicole, Shah, Rishita, Kelemen, Rachel, Klein, Peter S., Gordienko, Dmitri, Brown, Nigel A., Wilkinson, Christopher J., Williams, Robin S. B.
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113673/
https://ncbi.nlm.nih.gov/pubmed/21652627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.084285
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