Design of antiangiogenic hypoxic cell radiosensitizers: 2-Nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1,3-dione moiety

We designed chiral 2-nitroimidazole derivatives containing a 2-aminomethylene-4-cyclopentene-1,3-dione moiety as antiangiogenic hypoxic cell radiosensitizers. Based on results of molecular orbital calculations, the 2-aminomethylene-4-cyclopentene-1,3-dione moiety is expected to show high electrophil...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Uto, Yoshihiro, Nagasawa, Hideko, Jin, Cheng-Zhe, Nakayama, Shinichi, Tanaka, Ayako, Kiyoi, Saori, Nakashima, Hitomi, Shimamura, Mariko, Inayama, Seiichi, Fujiwara, Tomoya, Takeuchi, Yoshio, Uehara, Yoshimasa, Kirk, Kenneth L., Nakata, Eiji, Hori, Hitoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113482/
https://ncbi.nlm.nih.gov/pubmed/18474428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.04.041
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge