Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

SUMMARY: Recurrent fusions of ETS genes are considered driving mutations in a diverse array of cancers, including Ewing’s sarcoma, acute myeloid leukemia, and prostate cancer. We investigate the mechanisms by which ETS fusions mediate their effects, and find that the product of the predominant ETS g...

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Главные авторы: Brenner, J. Chad, Ateeq, Bushra, Li, Yong, Yocum, Anastasia K., Cao, Qi, Asangani, Irfan A., Patel, Sonam, Wang, Xiaoju, Liang, Hallie, Yu, Jindan, Palanisamy, Nallasivam, Siddiqui, Javed, Yan, Wei, Cao, Xuhong, Mehra, Rohit, Sabolch, Aaron, Basrur, Venkatesha, Lonigro, Robert J., Yang, Jun, Tomlins, Scott A, Maher, Christopher A., Elenitoba-Johnson, Kojo S.J., Hussain, Maha, Navone, Nora M., Pienta, Kenneth J., Varambally, Sooryanarayana, Feng, Felix Y., Chinnaiyan, Arul M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113473/
https://ncbi.nlm.nih.gov/pubmed/21575865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.04.010
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