Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

SUMMARY: Recurrent fusions of ETS genes are considered driving mutations in a diverse array of cancers, including Ewing’s sarcoma, acute myeloid leukemia, and prostate cancer. We investigate the mechanisms by which ETS fusions mediate their effects, and find that the product of the predominant ETS g...

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Main Authors: Brenner, J. Chad, Ateeq, Bushra, Li, Yong, Yocum, Anastasia K., Cao, Qi, Asangani, Irfan A., Patel, Sonam, Wang, Xiaoju, Liang, Hallie, Yu, Jindan, Palanisamy, Nallasivam, Siddiqui, Javed, Yan, Wei, Cao, Xuhong, Mehra, Rohit, Sabolch, Aaron, Basrur, Venkatesha, Lonigro, Robert J., Yang, Jun, Tomlins, Scott A, Maher, Christopher A., Elenitoba-Johnson, Kojo S.J., Hussain, Maha, Navone, Nora M., Pienta, Kenneth J., Varambally, Sooryanarayana, Feng, Felix Y., Chinnaiyan, Arul M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113473/
https://ncbi.nlm.nih.gov/pubmed/21575865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.04.010
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