IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi sarcoma associated herpesvirus infection

Inflammasomes are cytoplasmic sensors of foreign molecules, including pathogens, and function to induce caspase-1 activation and IL-1β cytokine maturation. Whether such a mechanism exists in the nucleus and is effective against nuclear replicating pathogens is unknown. Nuclear replicating herpesviru...

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Bibliografiske detaljer
Main Authors: Kerur, Nagaraj, Veettil, Mohanan Valiya, Sharma-Walia, Neelam, Bottero, Virginie, Sadagopan, Sathish, Otageri, Pushpalatha, Chandran, Bala
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113467/
https://ncbi.nlm.nih.gov/pubmed/21575908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.04.008
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