Characterization of Entry and Infection of Monocytic THP-1 cells by Kaposi's Sarcoma Associated Herpesvirus (KSHV): Role of Heparan Sulfate, DC-SIGN, Integrins and Signaling

KSHV effectively binds, enters and establishes infection in THP1 cells with initial concurrent expression of latent ORF73 and lytic ORF50 genes and subsequent persistence of ORF 73. KSHV genome persisted for 30 days and lytic cycle could be activated. KSHV utilized heparan sulfate for binding to THP...

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Autors principals: Kerur, Nagaraj, Veettil, Mohanan Valiya, Sharma-Walia, Neelam, Sadagopan, Sathish, Bottero, Virginie, Paul, Arun George, Chandran, Bala
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932840/
https://ncbi.nlm.nih.gov/pubmed/20674951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.07.012
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