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ClpA mediates directional translocation of substrate proteins into the ClpP protease

The intracellular degradation of many proteins is mediated in an ATP-dependent manner by large assemblies comprising a chaperone ring complex associated coaxially with a proteolytic cylinder, e.g., ClpAP, ClpXP, and HslUV in prokaryotes, and the 26S proteasome in eukaryotes. Recent studies of the ch...

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Autors principals: Reid, Brian G., Fenton, Wayne A., Horwich, Arthur L., Weber-Ban, Eilika U.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC31127/
https://ncbi.nlm.nih.gov/pubmed/11259663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.071043698
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