The multi-targeted receptor tyrosine kinase inhibitor, Linifanib (ABT-869), induces apoptosis through an AKT and Glycogen Synthase Kinase 3β-dependent pathway

The FMS-like receptor tyrosine kinase 3 (FLT3) plays an important role in controlling differentiation and proliferation of hematopoietic cells. Activating mutations in FLT3 occur in patients with acute myeloid leukemia (15-35%) resulting in abnormal cell proliferation. Furthermore, both adult and pe...

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Bibliographic Details
Main Authors: Hernandez-Davies, Jenny E., Zape, Joan P., Landaw, Elliot M., Tan, Xiaolin, Presnell, Ajia, Griffith, Diana, Heinrich, Michael C., Glaser, Keith B, Sakamoto, Kathleen M
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112478/
https://ncbi.nlm.nih.gov/pubmed/21471285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0904
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