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Overexpression of mitotic centromere associated kinesin stimulates microtubule detachment and confers resistance to paclitaxel

Numerous studies have implicated mutations in tubulin or the overexpression of specific tubulin genes in resistance to microtubule targeted drugs. Much less is known about the role of accessory proteins that modulate microtubule behavior in the genesis of drug resistance. Here we examine mitotic cen...

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Hlavní autoři: Ganguly, Anutosh, Yang, Hailing, Cabral, Fernando
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112244/
https://ncbi.nlm.nih.gov/pubmed/21471284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-1109
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