Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species

AIMS: Angiotensin II (Ang II) type AT(1) receptors expressed on vascular smooth muscle cells (VSMCs) couple to the Jak2 signalling pathway. However, the importance of this tissue-specific coupling is poorly understood. The purpose of this investigation was to determine the importance of VSMC-derived...

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Autors principals: Kirabo, Annet, Kearns, Patrick N., Jarajapu, Yagna P., Sasser, Jennifer M., Oh, Suk Paul, Grant, Maria B., Kasahara, Hideko, Cardounel, Arturo J., Baylis, Chris, Wagner, Kay-Uwe, Sayeski, Peter P.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112021/
https://ncbi.nlm.nih.gov/pubmed/21354995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr059
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