HAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin VH locus.

We have identified and sequenced 14 human immunoglobulin VH segments cloned in a yeast artificial chromosome, and have used a rapid PCR-based technique (HAPPY mapping, 12) to derive the order and approximate distances between them. The sequences mapped comprise thirteen germline VH segments and one...

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Bibliographic Details
Main Authors: Walter, G, Tomlinson, I M, Cook, G P, Winter, G, Rabbitts, T H, Dear, P H
Format: Artigo
Language:Inglês
Published: 1993
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC311185/
https://ncbi.nlm.nih.gov/pubmed/8233786
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