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The 5' flanking sequence negatively modulates the in vivo expression and in vitro transcription of a human tRNA gene.
The consequences of altering the 5' flanking region of a human amber suppressor tRNA(ser) gene on phenotypic expression in vivo and transcription in vitro was examined by constructing a series of upstream deletion and substitution mutants. The resulting tDNA variants were examined for functiona...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1993
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC311178/ https://ncbi.nlm.nih.gov/pubmed/8233781 |
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