The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage.

The synthesis is described of oligoribonucleotides containing the modified nucleoside O6-methylguanosine. Solid-phase oligoribonucleotide assembly was carried out by use of 2'-silyl-protected nucleoside phosphoramidites, a new O6-methylguanosine-containing synthon and a mild deprotection method...

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Bibliographic Details
Main Authors: Grasby, J A, Jonathan, P, Butler, G, Gait, M J
Format: Artigo
Language:Inglês
Published: 1993
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC311174/
https://ncbi.nlm.nih.gov/pubmed/8233777
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