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Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity

SKN-1, the Caenorhabditis elegans Nrf1/2/3 ortholog, promotes both oxidative stress resistance and longevity. SKN-1 responds to oxidative stress by upregulating genes that detoxify and defend against free radicals and other reactive molecules, a SKN-1/Nrf function that is both well-known and conserv...

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Autori principali: Li, Xuan, Matilainen, Olli, Jin, Congyu, Glover-Cutter, Kira M., Holmberg, Carina I., Blackwell, T. Keith
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111486/
https://ncbi.nlm.nih.gov/pubmed/21695230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002119
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