Matrix Metalloproteinase-8 Mediates the Unfavorable Systemic Impact of Local Irradiation on Pharmacokinetics of Anti-Cancer Drug 5-Fluorouracil

Concurrent chemoradiation with 5-fluorouracil (5-FU) is widely accepted for cancer treatment. However, the interactions between radiation and 5-FU remain unclear. Here, we evaluated the influence of local irradiation on the pharmacokinetics of 5-FU in rats. The single-fraction radiation was delivere...

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Autori principali: Hsieh, Chen-Hsi, Liu, Chia-Yuan, Hsieh, Yen-Ju, Tai, Hung-Chi, Wang, Li-Ying, Tsai, Tung-Hu, Chen, Yu-Jen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111455/
https://ncbi.nlm.nih.gov/pubmed/21695264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021000
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