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Akt phosphorylates and regulates the orphan nuclear receptor Nur77

The immediate early gene NUR77 (also called NGFI-B) is required for T cell antigen receptor-mediated cell death and is induced to very high levels in immature thymocytes and T cell hybridomas undergoing apoptosis. The Akt (PKB) kinase is a key player in transduction of anti-apoptotic and proliferati...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Pekarsky, Yuri, Hallas, Cora, Palamarchuk, Alexey, Koval, Anatoliy, Bullrich, Florencia, Hirata, Yoko, Bichi, Roberta, Letofsky, Jean, Croce, Carlo M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31113/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274386/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051003198
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