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Epigenetic Silencing of ALDH1L1, a Metabolic Regulator of Cellular Proliferation, in Cancers

FDH (10-formyltetrahydrofolate dehydrogenase, the product of the ALDH1L1 gene), a major folate-metabolizing enzyme in the cytosol, is involved in the regulation of cellular proliferation. We have previously demonstrated that FDH is strongly and ubiquitously down-regulated in malignant human tumors a...

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Autors principals: Oleinik, Natalia V., Krupenko, Natalia I., Krupenko, Sergey A.
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111244/
https://ncbi.nlm.nih.gov/pubmed/21779486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601911405841
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