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Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression
ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is the enzyme in folate metabolism commonly downregulated in human cancers. One of the mechanisms of the enzyme downregulation is methylation of the promoter of the ALDH1L1 gene. Recent studies underscored ALDH1L1 as a candidate tumor suppr...
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| Pubblicato in: | Chem Biol Interact |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6433412/ https://ncbi.nlm.nih.gov/pubmed/30794800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2019.02.013 |
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