TCR stimulation drives cleavage and shedding of the ITIM receptor CD31

CD31 is a transmembrane molecule endowed with T-cell regulatory functions due to the presence of 2 ITIMs. For reasons not understood, CD31 is lost by a portion of circulating T-lymphocytes, which appear prone to uncontrolled activation. Here we show that extracellular T-cell CD31 comprising Ig-like...

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Hauptverfasser: Fornasa, Giulia, Groyer, Emilie, Clement, Marc, Dimitrov, Jordan, Compain, Caroline, Gaston, Anh-Thu, Varthaman, Aditi, Khallou-Laschet, Jamila, Newman, Debra K., Graff-Dubois, Stéphanie, Nicoletti, Antonino, Caligiuri, Giuseppina
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association of Immunologists 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110943/
https://ncbi.nlm.nih.gov/pubmed/20400708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902219
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