5-Hydroxytryptophan during critical postnatal period improves cognitive performances and promotes dendritic spine maturation in genetic mouse model of phenylketonuria

Although phenylketonuria (PKU) is the most common genetic cause of mental retardation, the cellular mechanisms underlying impaired brain function are still unclear. Using PAH(enu2) mice (ENU2), the genetic mouse model of PKU, we previously demonstrated that high phenylalanine levels interfere with b...

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Bibliographische Detailangaben
Hauptverfasser: Andolina, Diego, Conversi, David, Cabib, Simona, Trabalza, Antonio, Ventura, Rossella, Puglisi-Allegra, Stefano, Pascucci, Tiziana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cambridge University Press 2011
Schlagworte:
Thematic Section: Consequences of Developmental Exposure to Drugs, Hormones or Altered Environment
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110346/
https://ncbi.nlm.nih.gov/pubmed/21040618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1461145710001288
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