5-Hydroxytryptophan during critical postnatal period improves cognitive performances and promotes dendritic spine maturation in genetic mouse model of phenylketonuria

Although phenylketonuria (PKU) is the most common genetic cause of mental retardation, the cellular mechanisms underlying impaired brain function are still unclear. Using PAH(enu2) mice (ENU2), the genetic mouse model of PKU, we previously demonstrated that high phenylalanine levels interfere with b...

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Detalhes bibliográficos
Main Authors: Andolina, Diego, Conversi, David, Cabib, Simona, Trabalza, Antonio, Ventura, Rossella, Puglisi-Allegra, Stefano, Pascucci, Tiziana
Formato: Artigo
Idioma:Inglês
Publicado em: Cambridge University Press 2011
Assuntos:
Thematic Section: Consequences of Developmental Exposure to Drugs, Hormones or Altered Environment
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110346/
https://ncbi.nlm.nih.gov/pubmed/21040618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1461145710001288
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