Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions

Notch signaling is essential for lymphocyte development and is also implicated in myelopoiesis. Notch receptors are modified by O-fucosylation catalyzed by protein O-fucosyltransferase 1 (Pofut1). Fringe enzymes add N-acetylglucosamine to O-fucose and modify Notch signaling by altering the sensitivi...

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Bibliografiske detaljer
Main Authors: Yao, David, Huang, Yuanshuai, Huang, Xiaoran, Wang, Weihuan, Yan, Quanjian, Wei, Lebing, Xin, Wei, Gerson, Stanton, Stanley, Pamela, Lowe, John B., Zhou, Lan
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110024/
https://ncbi.nlm.nih.gov/pubmed/21464368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-326074
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